Human biological fluids such as serum, urine, gastric juice, amniotic fluid, digestive, urinary and reproductive tracts, endocrine glands, middle ear, cerebrospinal and alveolar lining fluid contain numerous surfactants, proteins, and lipids. Many biological performances and natural processes involve an understanding of wetting and interfacial tension where most biochemical reactions occur not in solution but at the surface and interface. Surface tension is a phenomenon that we see in our everyday life. We therefore expect that studies of surface tension behavior of human biological fluids will provide additional useful information in medical practice. The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy. Theoretical background on surface tension measurement and surface tension values of reference fluids obtained from healthy and sick patients are depicted.Ĭonclusion: It is well accepted that no single biomarker will be effective in clinical diagnosis. It is expected that studies of surface tension behavior of human biological fluids will provide additional information and might become useful in medical practice. Results: Dynamic surface tension measurements of human biological fluids depend on various parameters such as sex, age and changes during pregnancy or certain disease. Methods: In this review, the variety of human diseases mediated by the surface tension changes of biological phenomena and the failure of biological fluids to remain in their native state are discussed. Surface tension of body fluids correlates directly to the development of pathological states. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human organs. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Introduction: Pathological features of disease appear to be quite different.
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